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SUMMARY:Rational design of Sn(IV) porphyrins for photodynamic therapy: fur
 ther progress and future perspectives
DTSTART;VALUE=DATE-TIME:20211202T123000Z
DTEND;VALUE=DATE-TIME:20211202T130000Z
DTSTAMP;VALUE=DATE-TIME:20260711T081004Z
UID:indico-contribution-1566@events.chpc.ac.za
DESCRIPTION:Speakers: John Mack (Rhodes University)\nOver the last year\, 
 considerable further progress has been made in using a rational design app
 roach [1] guided by calculations with the Gaussian 09 software package on 
 the Lengau cluster and an application of Michl’s perimeter model [1\,2] 
 to prepare novel Sn(IV) complexes of porphyrin dyes and porphyrin analogue
 s that are suitable for use as photosensitizer dyes in photodynamic therap
 y [3-8]. Axial ligation results in low levels of aggregation\, while the S
 n(IV) ion promotes intersystem crossing resulting in relatively high singl
 et oxygen quantum yields through a heavy atom effect. Relatively low IC50 
 values have been obtained during *in vitro* studies against MCF-7 breast c
 ancer cells [3-9]. Future directions on the use of the Gaussian 09 softwar
 e package in the context of this research will be described.\n**References
 **\n[1] J. Mack\, *Chem. Rev.* **2017**\, *117*\, 3444-3478.\n[2] J. Michl
 \, *Tetrahedron* **1984**\, *40*\, 3845-3934.\n[3] B. Babu\, J. Mack\, T. 
 Nyokong\, *Dalton Trans.* **2020**\, *49*\, 9568-9573.\n[4] B. Babu\, E. P
 rinsloo\, J. Mack\, T. Nyokong\, *New J. Chem.*\, **2020**\, *44*\, 11006-
 11012.\n[5] B. Babu\, J. Mack\, T. Nyokong\, *Dalton Trans.* **2020**\, *4
 9*\, 15180-15183.\n[6] B. Babu\, J. Mack\, T. Nyokong\, *Dalton Trans.* **
 2021**\, *50*\, 2177-2182.\n[7] B. Babu\, J. Mack\, T. Nyokong\, *New J. C
 hem.*\, **2021**\, *45*\, 5654-5658.\n[8] R.C. Soy\, B. Babu\, J. Mack\, T
 . Nyokong\, *Dyes Pigments*\, **2021**\, *194*\, 109631.\n[9] B. Babu\, A.
  Sindelo\, J. Mack\, T. Nyokong\, Dyes Pigments\, **2021**\, 185A\, 108886
 .\n\nhttps://events.chpc.ac.za/event/98/contributions/1566/
LOCATION:
URL:https://events.chpc.ac.za/event/98/contributions/1566/
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